Methocarbamol 750 mg

Each tablet contains:

Methocarbamol 750 mg

Size: 50
Item Form: ER Tablets
Flavor: None

Drug class:

Muscle Relaxants.

General information:

Methocarbamol can impair mental and/or physical abililties required for performance of hazardous tasks, such as driving or operating machinery. These effects may be additive with ethanol ingestion or coadministration with other CNS depressants. Patients should be cautioned about operating machinery, including automobiles, until they are certain that methocarbamol does not adversely affect their ability to engage in such activities.

Missed dose: if a dose is missed, take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Mechanism of Action:

The exact mechanism of action of methocarbamol is unknown. Unlike neuromuscular blockers, methocarbamol does not have an effect on neuronal conduction, neuromuscular transmission, or muscle excitability. Similar to carisoprodol, chlorzoxazone, and cyclobenzaprine, methocarbamol has no direct effect on skeletal muscle. Its skeletal muscle relaxant effects are probably due to its central nervous system depressant effects. CNS depression leads to sedation and a reduction in skeletal muscle spasms. These effects are accompanied by relief of pain and an increase in the mobility of the affected muscles. Pain relief is postulated to be due to alterations in the perception of pain.

Indications and Dosage:


Musculoskeletal condition:

Initially, 1,500 mg PO 4 times per day for 2 to 3 days (total 6 grams/day PO for the first 24 to 78 hours). Max acute dose (first 48 to 72 hours): 8 grams/day PO for severe conditions. Then, reduce to either 1,000 mg PO 4 times per day, 1,500 mg PO 3 times per day, or, 750 mg PO every 4 hours. Usual maintenance 4 grams/day PO in divided doses. Max maintenance: 4.5 grams/day PO in divided doses.


Methocarbamol is contraindicated for use by patients hypersensitive to methocarbamol or to any component of the formulation.


Category C

Safe use of methocarbamol has not been established with regard to possible adverse effect upon fetal development. Therefore, do not use methocarbamol tablets in women who are, or may become pregnant, particularly during early pregnancy unless the potential benefits outweigh the possible hazards.


It is not known if methocarbamol or its metabolites are excreted in human milk. Methocarbamol should be used with caution during breast-feeding.


  • Pediatric: Safety and efficacy of methocarbamol in children younger than 16 years of age have not been established.
  • Elderly: Use methocarbamol with caution in the geriatric patient due to slight pharmacokinetic alterations observed vs. younger adults. Methocarbamol is not generally preferred for use in geriatric patients because of the potential risk for side effects.
  • Cautious use of methocarbamol is warranted for patients with severe hepatic disease.


Alcohol ( Ethyl ), Azelastine (Nasal), Blonanserin, Brimonidine (Topical),  Buprenorphine, Cannabis, CNS depressants, Doxylamine, Dronabinol, Dropridol, Eperisone, Hydrocodone, Hydroxyzine, Kava Kava, Magnesium sulfate, Methotrimeprazine, Metyrozine, Minocycline, Mirtazapine, Nabilone, Orphenadrine, Oxycodone, Paraldehyde, Perampanel, Pramipexole, Pyridostigmine, Ropirinole, Rotigotine, Rufinamide, SSRIs, Sodium Oxybate, Suvorexant, Tapentadol, Tetrahydrocannabinol, Thalidomide, Trimeprazine, Zolpidem.

Adverse reactions:

Cardiovascular: Bradycardia, flushing, hypotension, syncope, Thrombophlebitis

CNS: Amnesia, confusion, diplopia, dizziness or light-headedness, drowsiness, insomnia, mild muscular incoordination, nystagmus, sedation, seizures ( including grand mal), vertigo.

Dermatologic: Pruritus, rush, urticarial.

GI: Dyspepsia, jaundice (including cholestatic jaundice), nausea, vomiting

Hematologic/Lymphatic: leukopenia.

Immunosuppression: Hypersensitivity reactions.

Special Senses: Blurred vision, conjunctivitis, nasal congestion, metallic taste.

Miscellaneouse: Anaphylactic reaction, angioneurotic edema, fever, headache.

Over dosage:

If you accidentally take too many Methocarbamol tablets or take a higher dose than recommended by your doctor, it is important that you tell your doctor at once. If you cannot contact your doctor, go to the nearest accident and emergency department.


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